Szucova, Lucie et al. published their research in Bioorganic & Medicinal Chemistry in 2006 | CAS: 203436-45-7

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity was written by Szucova, Lucie;Travnicek, Zdenek;Zatloukal, Marek;Popa, Igor. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Category: chlorides-buliding-blocks This article mentions the following:

The Pt(II) and Pd(II) complexes of the types cis-[Pt(L1)2Cl2]·H2O (1), cis-[Pt(L2)2Cl2]·3H2O (2), trans-[Pd(L1)2Cl2]·H2O (3), trans-[Pd(L2)2Cl2]·H2O (4), trans-[Pd(L3)2Cl2]·2DMF (5) and trans-[Pd(L4)2Cl2]·2DMF (6) (L1-L4 = cyclin-dependent kinase inhibitors derived from 6-benzylamino-9-isopropylpurine) have been prepared and characterized. The complexes have been studied by elemental analyses, conductivity measurements, ES+ MS, FT-IR, 1H, 13C and 195Pt NMR spectra, differential scanning calorimetry and thermogravimetric anal. The mol. structures of L1, trans-[Pd(L3)2Cl2]·2DMF (5) and trans-[Pd(L4)2Cl2]·2DMF (6) have been determined by single crystal x-ray anal. The complexes have been tested in vitro due to their presumable anticancer activity against the following human cancer cell lines: K-562, MCF7, G-361 and HOS. Satisfying results were obtained for the complex 1 with IC50 values of 6 μM acquired against G-361 as well as against HOS cell lines. The lowest values of IC50 were achieved for the complexes 3 and 4 against MCF 7 cell line with IC50 3 μM (for 3) and also 3 μM (for 4). In the experiment, the researchers used many compounds, for example, 2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7Category: chlorides-buliding-blocks).

2,6-Dichloro-9-isopropyl-9H-purine (cas: 203436-45-7) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics