5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid
Development, synthesis, and biological evaluation of sulfonyl-α-L-amino acids as potential anti-Helicobacter pylori and IMPDH inhibitors was written by Galal, Alaaeldin M. F.;Mohamed, Hanaa S.;Abdel-Aziz, Marwa M.;Hanna, Atef G.. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2021.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid This article mentions the following:
IMP dehydrogenase (IMPDH) catalyzes a crucial step in the biosynthesis of DNA and RNA, and it has been exploited as a promising target for antimicrobial therapy. The present study discusses the development and synthesis of a series of sulfonyl-α-L-amino acids coupled with the anisamide scaffold and evaluates their activities as anti-Helicobacter pylori and IMPDH inhibitors. Twenty derivatives were synthesized and their structures were established by high-resolution mass spectrometry and 1H and 13C NMR measurements. Four compounds (I) (R1 = L-Val, L-Leu, L-Ile, L-Trp) were found to be the most potent and selective mols. in the series with min. inhibitory concentration (MIC) values <17μM, which were selected to test their inhibitory activities against HpIMPDH and human (h)IMPDH2 enzymes. In all tests, amoxicillin and clarithromycin were used as reference drugs. Compounds I (R1 = L-Val, L-Leu) were found to have a promising activity against the HpIMPDH enzyme, with IC50 = 2.42 and 2.56μM, resp. Moreover, the four compounds were found to be less active and safer against hIMPDH2 than the reference drugs, with IC50 > 17.17μM, which makes sure that their selectivity is toward HpIMPDH and reverse to that of amoxicillin and clarithromycin. Also, the synergistic antibacterial activity of compounds I (R1 = L-Val, L-Leu) amoxicillin, and clarithromycin was investigated in vitro. The combination of amoxicillin/compound I (R1 = L-Val) (2:1 by weight) exhibited a significant antibacterial activity against H. pylori, with MIC = 0.12μg/mL. The mol. docking study and ADMET anal. of the most active compounds were used to elucidate the mode-of-action mechanism. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Application In Synthesis of 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application In Synthesis of 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics