Nickel-catalyzed ortho-halogenation of unactivated (hetero)aryl C-H bonds with lithium halides using a removable auxiliary was written by Zhan, Bei-Bei;Liu, Yan-Hua;Hu, Fang;Shi, Bing-Feng. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.HPLC of Formula: 36157-41-2 This article mentions the following:
The first example of Ni-catalyzed halogenation of (hetero)aryl C-H bonds with lithium halides (LiX, X = Br, I, Cl) using PIP as a removable directing group was reported. This protocol provided an efficient access to ortho-halogenated (hetero)arenes with operational simplicity, good functional group tolerance and large-scale synthesis. In the experiment, the researchers used many compounds, for example, 2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2HPLC of Formula: 36157-41-2).
2,5-Dichlorothiophene-3-carboxylic acid (cas: 36157-41-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 36157-41-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics