Synthesis and QSAR studies of thiosemicarbazides, 1,2,4-triazoles, 1,3,4-thiadiazoles and 1,3,4-oxadiazoles derivatives as potential antibacterial agents was written by Desai, N. C.;Bhavsar, A. M.;Shah, M. D.;Saxena, Anil K.. And the article was included in Indian Journal of Chemistry in 2008.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate This article mentions the following:
Several new 2-(2-(4-chlorophenyl)acetyl)-N-arylhydrazinecarbothioamides, e.g., I, 5-(4-chlorobenzyl)-4-aryl-4H-1,2,4-triazole-3-thiols, e.g., II, 5-(4-chlorobenzyl)-N-aryl-1,3,4-thiadiazol-2-amines, e.g., III (X = S), and 5-(4-chlorobenzyl)-N-aryl-1,3,4-oxadiazol-2-amines, e.g., III (X = O), have been synthesized and screened for their antibacterial activity against the gram pos. and gram neg. bacteria S. aureus and E. coli. The QSAR studies of these compounds have been carried out in terms of structural and physicochem. parameters. A pos. contribution of bulkier substituents present at position 2 of I indicates an increase in hydrophobicity or steric bulk character. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Application In Synthesis of 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application In Synthesis of 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics