Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors was written by Gilbert, Eric J.;Zhou, Guowei;Wong, Michael K. C.;Tong, Ling;Shankar, Bandarpalle B.;Huang, Chunli;Kelly, Joseph;Lavey, Brian J.;McCombie, Stuart W.;Chen, Lei;Rizvi, Razia;Dong, Youhao;Shu, Youheng;Kozlowski, Joseph A.;Shih, Neng-Yang;Hipkin, R. William;Gonsiorek, Waldemar;Malikzay, Asra;Lunn, Charles A.;Favreau, Len;Lundell, Daniel J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Related Products of 18437-66-6 This article mentions the following:
The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 inhibition is described. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Related Products of 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics