Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist was written by Hu, Lijun;Ren, Qiang;Deng, Liming;Zhou, Zongtao;Cai, Zongyu;Wang, Bin;Li, Zheng. And the article was included in European Journal of Medicinal Chemistry in 2021.COA of Formula: C8H9Cl This article mentions the following:
Farnesoid X receptor (FXR), a bile acid-activated nuclear receptor, regulates the metabolism of bile acid and lipids as well as maintains the stability of internal environment. FXR was considered as a therapeutic target of liver disorders, such as drug-induced liver injury, fatty liver and cholestasis. The previous reported FXR partial agonist I was a suitable lead compound in terms of its high potent and low mol. size, while the docking study of compound I suggested a large unoccupied hydrophobic pocket, which might be provided more possibility of structure-activity relationship (SAR) study. In this study, we have performed comprehensive SAR and mol. modeling studies based on lead compound I. All of these efforts resulted in the identification of a novel series of FXR partial agonists. In this series, compound II revealed the best activity and strong interaction with binding pocket of FXR. Moreover, compound II protected mice against acetaminophen-induced hepatotoxicity by the regulation of FXR-related gene expression and improving antioxidant capacity. In summary, these results suggest that compound II is a promising FXR partial agonist suitable for further investigation. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9COA of Formula: C8H9Cl).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C8H9Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics