Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives was written by Yin, Yu-dong;Liu, Jing-jing;Liao, Wen-fei;Guo, Xian-kun;Zhang, Li-shan;Mo, Wei-bin;Cheng, Ke-guang. And the article was included in Medicinal Chemistry Research in 2021.COA of Formula: C19H15Cl This article mentions the following:
As 17β-estradiol and its derivatives have good affinity with estrogen receptors and have unique antitumor properties, O1-propargyl-N4,N4-bis(2-chloroethyl)-4-aminophenol and N4,N4-dipropargyl-N1,N1-bis(2-chloroethyl)-1,4-phenylenediamine were resp. combined with 17β-estradiol through linkers of different lengths. These targeted novel nitrogen mustard 17β-estradiol derivatives were tested antiproliferative activity using the MTT assay. The results illustrated that these compounds were less toxicity to HL-7702 (human liver cells) and SKOV-3, though all their activity potency was moderate or weak against the MDA-MB-231, MCF-7 and BEL-7404 cell lines. The inhibitory activity of the O1-propargyl-N4,N4-bis (2-chloroethyl)-4-aminophenol derivatives were obviously better than the N4-dipropargyl-N1, N1-bis (2-chloroethyl) -1,4-phenylenediamine derivatives against tested tumor cell lines. And three hybrids exhibited good inhibitory activity against BEL-7404 cell line (IC50 = 13.5, 15.3 and 13.9μM, resp.). After that, we performed KEGG pathway anal. on one compound, and the results showed that it mainly induced breast cancer cell apoptosis by regulating the expression of the proteins in NF-κ B pathway. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5COA of Formula: C19H15Cl).
(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C19H15Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics