Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties was written by Oost, Thorsten;Backfisch, Gisela;Bhowmik, Swati;van Gaalen, Marcel M.;Geneste, Herve;Hornberger, Wilfried;Lubisch, Wilfried;Netz, Astrid;Unger, Liliane;Wernet, Wolfgang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Computed Properties of C8H9ClO4S This article mentions the following:
Herein we report the discovery of a novel series of vasopressin 1b (V1b) receptor antagonists, starting from potent but metabolically labile oxindole SSR149415. Masking the proline N,N-di-Me amide moiety as an oxazole and attaching a benzylic amine moiety to the northern Ph ring resulted in potent and selective V1b receptor antagonists with improved metabolic stability and improved pharmacokinetic properties in rat. Compound 18c (I) was found to be efficacious in a rat model of anti-depressant activity. In the experiment, the researchers used many compounds, for example, 2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2Computed Properties of C8H9ClO4S).
2,4-Dimethoxybenzene-1-sulfonyl chloride (cas: 63624-28-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C8H9ClO4S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics