Nitrophenyl Derivatives as Aldose Reductase Inhibitors was written by Costantino, Luca;Ferrari, Anna Maria;Gamberini, Maria Cristina;Rastelli, Giulio. And the article was included in Bioorganic & Medicinal Chemistry in 2002.SDS of cas: 16588-16-2 This article mentions the following:
Nitrophenyl derivatives were recently discovered as a new class of ALR2 inhibitors by means of docking and database screening of the National Cancer Institute database of organic mols. The nitro group was predicted to bind to the Tyr48 and His110 active site residues of the enzyme, the site where acidic ALR2 inhibitors such as carboxylic acids bind in their anionic form. Given the novelty of these compounds, we decided to expand their structure-activity relationships by synthesizing and testing a series of derivatives and the corresponding compounds having a carboxylic group instead of the nitro moiety; the results obtained were rationalized by means of docking and mol. dynamics simulations. On the whole there is an agreement between inhibitory data and the results of mol. modeling experiments, supporting the hypothesized binding mode of these compounds In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2SDS of cas: 16588-16-2).
Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 16588-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics