Ramya, Posa Venkata Sri et al. published their research in ChemistrySelect in 2018 | CAS: 34662-36-7

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 34662-36-7

Synthesis and Biological Evaluation of Thieno[2,3-d]pyrimidine-amides as Potential Anticancer Agents was written by Ramya, Posa Venkata Sri;Thatikonda, Sowjanya;Angapelly, Srinivas;Babu, Bathini Nagendra;Naidu, Vegi Ganga Modi;Kamal, Ahmed. And the article was included in ChemistrySelect in 2018.Reference of 34662-36-7 This article mentions the following:

A new class of N-(3-(thieno[2,3-d]pyrimidin-4-ylamino)phenyl)amides I [R = Ph, 4-MeC6H4, 2-CF3C6H4, etc.] were synthesized and examined for their anticancer activity towards different human cancer cell lines. Out of the tested derivatives, compounds I [R = 4-FC6H4, 2-NO2-5-CH3C6H3, 3-CF3C6H4CH=CH, stereo = E] displayed potent growth inhibition on some of the cell lines, peculiarly I [R = 3-CF3C6H4CH=CH, stereo = E] exhibited selective and promising activity on MDA-MB-453 and MCF-7 cell lines. In comparison to the standard ZSTK474, nearly 3 fold growth inhibitory effect was noticed with I [R = 3-CF3C6H4CH=CH, stereo = E] against MCF-7 cell line. The morphol. and long term clonogenic survival of MCF-7 cells were affected by compound I [R = 3-CF3C6H4CH=CH, stereo = E]. The results from AO/EB and DAPI staining studies as well as anal. of mitochondrial membrane potential divulged that the growth of MCF-7 cells was inhibited by I [R = 3-CF3C6H4CH=CH, stereo = E] through the induction of apoptosis. From flow-cytometry anal., it was notable that I [R = 3-CF3C6H4CH=CH, stereo = E] shows G0/G1 cell cycle arrest in MCF-7 cells. In the experiment, the researchers used many compounds, for example, 3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7Reference of 34662-36-7).

3-Chloro-5-nitrobenzoic acid (cas: 34662-36-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 34662-36-7

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics