Palladium-Catalyzed α-Arylation of Tetramic Acids was written by Storgaard, Morten;Zaragoza Doerwald, Florencio;Peschke, Bernd;Tanner, David. And the article was included in Journal of Organic Chemistry in 2009.Recommanded Product: 18437-66-6 This article mentions the following:
A mild, racemization-free, palladium-catalyzed α-arylation of tetramic acids (2,4-pyrrolidinediones) has been developed. Various amino acid-derived tetramic acids were cleanly arylated by treatment with 2 mol % of Pd(OAc)2, 4 mol % of a sterically demanding biaryl phosphine, 2.3 equiv of K2CO3 or K3PO4, and aryl chlorides, bromides, or triflates in THF. With conventional heating, conversions >95% could be attained after 1 h at 80 °C, whereas microwave-induced heating led to much shorter reaction times (5 min at 110 °C). The electron d. of the aryl electrophile had no effect on their reactivity: both electron-rich and electron-poor aryl chlorides and bromides or triflates led to good yields. Ortho-substituted aryl halides and heteroaryl halides, however, did not undergo the title reaction. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Recommanded Product: 18437-66-6).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 18437-66-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics