Crude extract of Origanum vulgare L. induced cell death and suppressed MAPK and PI3/Akt signaling pathways in SW13 and H295R cell lines was written by Rubin, Beatrice;Mansi, Jacopo;Monticelli, Halenya;Bertazza, Loris;Redaelli, Marco;Sensi, Francesca;Zorzan, Maira;Scaroni, Carla;Mian, Caterina;Iacobone, Maurizio;Armanini, Decio;Bertolini, Cristina;Barollo, Susi;Boscaro, Marco;Pezzani, Raffaele. And the article was included in Natural Product Research in 2019.COA of Formula: C18H37Cl This article mentions the following:
Oregano (Origanum vulgare L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumor cell models. This study analyzed for the first time the anticancer effects of a crude extract of wild mountain oregano (Origanum vulgare L.) in SW13 and H295R cell lines. The crude extract was characterised by GC/MS and the toxic effects of oregano were first analyzed by brine shrimp lethality assay. Our findings demonstrated that oregano decreased cell viability, survival, modified cell cycle and induced cell death (through necrotic process) and that the effects can be attributed to a blockade of MAPK and PI3 K/Akt pathways. These results suggest that oregano extract exerts anticancer activities in adrenocortical tumor cell lines, providing evidence for further research in higher models. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2COA of Formula: C18H37Cl).
1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.COA of Formula: C18H37Cl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics