KMnO4-mediated oxidative C-N bond cleavage of tertiary amines: Synthesis of amides and sulfonamides was written by Zhang, Zhang;Liu, Yong-Hong;Zhang, Xi;Wang, Xi-Cun. And the article was included in Tetrahedron in 2019.COA of Formula: C8H10ClN This article mentions the following:
KMnO4-mediated oxidative C-N bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction took placeat mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 2-Chloro-N,N-dimethylaniline (cas: 698-01-1COA of Formula: C8H10ClN).
2-Chloro-N,N-dimethylaniline (cas: 698-01-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C8H10ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics