N-alkylation and o-alkylation of ethyl 4-(4,6-dimethoxypyrimidin-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxylate was written by Li, Yuanxiang. And the article was included in Youji Huaxue in 2013.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene This article mentions the following:
Twenty novel N-substituted and O-substituted compounds were prepared starting from Et 4-(4,6-dimethoxypyrimidin-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxylate. Various halogenated hydrocarbons were used as resource of alkylation and NaH as base in N,N-dimethylformamide (DMF) at room temperature. The structures of alkylation products were confirmed by ‘H NMR, IR, MS and elemental anal. Two isomer structures were further determined by representative X-ray structures of I and II. The alkylation reaction was performed in mild conditions with a total yield of 89%-98%. Among them, the main product N-alkylation was obtained in 47%-77% yield, and O-alkylation was simultaneously obtained in 21%-49% yield by a simple one-pot reaction. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 2-(Chloromethyl)-1,3-difluorobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics