Practical synthesis of iminochlorothioformates: application of iminochlorothioformates in the synthesis of novel 2,3,4,9-tetrahydroisothiazolo[5,4-b][1,8]naphthyridine-3,4-diones and 2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione derivatives was written by Chu, Daniel T. W.;Claiborne, Akiyo K.. And the article was included in Journal of Heterocyclic Chemistry in 1990.COA of Formula: C10H8Cl2FNO3 This article mentions the following:
The synthesis of fluoropiperazinylcyclopropyltetrahydroisothiazolonaphthyridinedione and difluoropiperazinylcyclopropyltetrahydroisothiazoloquinolinediones I (X = N, CF) is described. The key step involves the one-pot formation of 2-phenylthio derivatives of dihydro-4-oxonaphthyridine-3-carboxylate II (R = Cl, X = N) and the corresponding quinoline derivative II (R = F, X = CF) by condensation of β-keto esters III with Ph iminochlorothioformate. A simple and practical synthesis of iminochlorothioformates using isothiocyanates and mercaptans is also described. In the experiment, the researchers used many compounds, for example, Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6COA of Formula: C10H8Cl2FNO3).
Ethyl 3-(2,6-Dichloro-5-fluoro-3-pyridyl)-3-oxopropionate (cas: 96568-04-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C10H8Cl2FNO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics