Hanessian, Stephen published the artcileDesign, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(6), 1972-1976, database is CAplus and MEDLINE.
Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives, e.g., I·HCl, were designed and synthesized having diverse functionality at the P1 and P3 sites. Potent in vitro activity against thrombin, with excellent selectivity over trypsin was found for selected analogs.
Bioorganic & Medicinal Chemistry Letters published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Recommanded Product: 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride.
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