Mohamed, Heba A. published the artcileSilver(I) N-Heterocyclic Carbene Complexes Derived from Clotrimazole: Antiproliferative Activity and Interaction with an Artificial Membrane-Based Biosensor, Formula: C19H14Cl2, the publication is Organometallics (2020), 39(8), 1318-1331, database is CAplus.
With the aim of combining the potential anticancer properties of both clotrimazole, an imidazole based antifungal agent, and Ag(I) N-heterocyclic carbenes, 13 novel Ag(I) N-heterocyclic carbene complexes derived from clotrimazole were synthesized. The complexes were fully characterized, and the partition coefficient of each provides a measure of hydrophobicity. The antiproliferative properties of the complexes against cancerous and noncancerous cell lines found optimum cytotoxicity when the complex displays an intermediate lipophilicity, which describes a complex that possesses both water-soluble groups and lipophilic aromatic groups. The Ag complexes were screened on a synthetic biomembrane-like device using a chip-based phospholipid-coated Pt/Hg electrode embedded in a flow cell system. The results are recorded as rapid cyclic voltammograms (RCVs), which give insight into the interactions of the complexes with a cell membrane. The principle of intermediate lipophilicity also applies to the monolayer interaction to which the Ag atom significantly implements an irreversibility.
Organometallics published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Formula: C19H14Cl2.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics