Mukhtar, Asma published the artcileSynthesis of Chalcones as Potential α-Glucosidase Inhibitors, In-Vitro and In-Silico Studies, HPLC of Formula: 19652-33-6, the publication is ChemistrySelect (2021), 6(37), 9933-9940, database is CAplus.
Seventeen chalcones derivatives I [R = 2-HO-3-ClC6H3, 4-NMe2C6H4, 2-Br-4,5-(OMe)2C6H2, etc.; R1 = 3-MeC6H4, 4-MeC6H4, 4-ClC6H4, etc.] were synthesized by reactions of diversely substituted aldehydes with various ketones. The structures of compounds were characterized by using NMR (NMR) spectroscopy, mass spectrometry (MS) and carbon, hydrogen, nitrogen (CHN) anal. These synthetic mols. were tested for α-glucosidase inhibitory activity. Acarbose was used as a standard drug and pos. control in this study. Compound I [R = 2-HO-3,5-Cl2C6H2; R1 = 4-MeC6H4] with hydroxy and chloro substitutions was found to be the most active compound and a novel compound of this library. Active mols. were subjected to in silico study to determine binding interactions with target site of α-glucosidase.
ChemistrySelect published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, HPLC of Formula: 19652-33-6.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics