Lee, Hui-Soon published the artcileEffect of substituents on benzenesulfonyl motif of 4-phenyl-1-arylsulfonylimidazolidinones for their cytotoxicity, Product Details of C10H11ClO2S, the publication is Archives of Pharmacal Research (2000), 23(6), 579-584, database is CAplus and MEDLINE.
To explore the effect of substituents on Ph motif on sulfonyl function of novel anticancer 4-phenyl-1-benzenesulfonylimidazolidinones, electron donating or withdrawing substituents were introduced at 3 or 4-position and the analogs were tested against human lung (A549) and colon (HCT-15) cancer cell lines. Quant. structure activity relation of the 4-substituted series shows that only STERIMOL L values are well correlated. The increment of substituent’s volume enhances the activity against both cell lines. The small substituent at 3-position addnl. increases the activity. However naphthyl group in place of Ph reduces the activity. Therefore the Ph motif with sterically large substituent at 4-position and small substituent at 3-position may be important for their activity. Integration of these substituents’ effects into the structural design led to discover the more potent analog, 4-phenyl-1-(N-acetylindoline-5-sulfonyl)imidazolidinone.
Archives of Pharmacal Research published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Product Details of C10H11ClO2S.
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