Gao, Yadong published the artcileDirect synthesis of annulated indoles through palladium-catalyzed double alkylations, HPLC of Formula: 23616-79-7, the publication is Organic Chemistry Frontiers (2020), 7(9), 1149-1157, database is CAplus.
A facile, one-step synthesis of annulated indoles I [R = H, 2-Me, 7-F, etc.; R1 = H, Me, Ph, etc.; n = 1,2,3] and II [R2 = H; R2R3 = (CH2)4, (CH2)3CH(Me), (CH2)2NPh(CH2)2, etc.; R4 = H, 2-CN, 6-NO2, etc.; R5 = H; R3R5 = (CH2)2NPh(CH2)2] from (N-H) indoles and dibromoalkanes was developed through a palladium-catalyzed double alkylation process. The reaction proceeded through a palladium-catalyzed norbornene-mediated C2-alkylation of indoles and subsequent regioselective cyclization. The detailed reaction mechanism was investigated by key intermediate experiments, NMR spectroscopic analyses and DFT calculations The results of a preliminary mechanistic study showed a catalytic cycle consisting of initial C2-alkylation of indoles that is followed by N-alkylation or palladium promoted intramol. C3-nucleophilic substitution to yield, resp., [a]- or [b]-annulated indoles.
Organic Chemistry Frontiers published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.
Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics