Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 622-86-6, name is (2-Chloroethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C8H9ClO
3- Bromophenylacetic acid (4.0 g, 18.6 mmol) was dissolved in trifluoroacetic anhydride (3.6 mL, 25.9 mmol), then (2-chloroethoxy)benzene (2.56 mL, 18.6 mmol) was added dropwise. The resulting mixture was allowed to stir at room temperature overnight. The reaction mixture was quenched with saturated aqueous sodium bicarbonate solution and then extracted twice with ethyl acetate. The organic layers were combined, dried over anhydrous magnesium sulfate and then concentrated on a rotary evaporator. The resulting residue was purified by chromatography on silica gel to afford the desired product (5.46 g, 83% yield) as a yellow solid. NMR (400 MHz, MeOD) delta 8.07 (d, J =8.9 Hz, 2H), 7.47-7.40 (m, 2H), 7.25-7.24 (m, 2H), 7.07(d, J = 8.9 Hz, 2H), 4.37-4.33 (m, 4H), 3.92-3.89 (m, 2H); MS (ESI) (m/z) 355 (M+H)+. (0862)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 622-86-6.
Reference:
Patent; TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; CHILDERS, Wayne, E.; ABOU-GHARBIA, Magid; JACOBSON, Marlene, A.; FAN, Rong; MARTINEZ, Rogelio, L.; MELENSKI, Edward, George; (126 pag.)WO2017/205451; (2017); A1;,
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