Electric Literature of 2687-12-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2687-12-9, name is Cinnamyl chloride, This compound has unique chemical properties. The synthetic route is as follows.
Representative experimental procedure for carboxylative coupling reaction Taking the carboxylative coupling of 4-methylphenylacetylene, cinnamyl chloride (2a), and CO2 as example: A 70 mL oven dried autoclave containing a stir bar was charged with AgI (0.5 mg, 0.002 mmol) and Cs2CO3 (978 mg, 3.0 mmol). 4-Methylphenylacetylene (232 mg, 2.0 mmol), cinnamyl chloride (458 mg, 3.0 mmol), and 20 mL dry DMF were added with syringe, respectively, after purging the autoclave with CO2 three times. The sealed autoclave was pressurized to appropriate pressure with CO2. The reaction mixture was stirred at 60 C for 24 h, then the autoclave was cooled to room temperature and the remaining CO2 was vented slowly. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (3*30 mL). The combined organic layers were washed with water and brine, dried over Na2SO4, and filtered. The solvent was removed under vacuum. The product (E)-cinnamyl 4-methylphenylpropiolate (3b) (502 mg, 1.82 mmol, 91% yield) was isolated by column chromatography on silica gel (ethyl acetate/petroleum ether: 1:25).
The chemical industry reduces the impact on the environment during synthesis Cinnamyl chloride. I believe this compound will play a more active role in future production and life.
Reference:
Article; Zhang, Xiao; Zhang, Wen-Zhen; Shi, Ling-Long; Zhu, Chuang; Jiang, Jiao-Lai; Lu, Xiao-Bing; Tetrahedron; vol. 68; 44; (2012); p. 9085 – 9089;,
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