Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 918538-05-3, name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine
Step 15) 2-chloro-N-(5-methyl-lH-pyrazol-3-yl)pyrrolor2.1-/iri.2.41triazin-4-amine [0344] To a solution of 2,4-dichloropyrrolo[2, l- ][l,2,4]triazine (999.5 mg, 5.3 mmol) and 5- methyl-lH-pyrazol-3-amine (516.3 mg, 5.3 mmol) in EtOH (20 mL) was added Et3N (1.08 g, 10.7 mmol). After addition, the reaction mixture was stirred at rt overnight and concentrated in vacuo. The residue was beated with a mixture of H20 and EtOH (5/1 (v/v), 12 mL) at rt for 0.5 h and filtered. The filter cake was washed with PE (20 mL x 3) to give the title compound as a pale yellow solid (1.25 g, 94.7%). MS (ESI, pos. ion) m/z: 249.1 [M+H]+; ‘H NMR (600 MHz, DMSO-Jd): delta (ppm) 12.33 (s, 1H), 11.01 (s, 1H), 7.74 (s, 1H), 7.34 (s, 1H), 6.70 (s, 1H), 6.54 (s, 1H), 2.27 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; LI, Minxiong; HU, Haiyang; DAI, Weilong; LI, Xiaobo; WANG, Tingjin; WU, Yanjun; (136 pag.)WO2016/190847; (2016); A1;,
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