Tan, Yi published the artcileSynthesis and antifungal activity of novel chiral indole analogues, Name: 2-Chloroisonicotinic acid, the publication is Natural Product Research, database is CAplus and MEDLINE.
Starting from L-tryptophan, 19 new N-substituted chiral indole analogs were synthesized. The prepared compounds were evaluated for biol. activity against Sclerotinia sclerotiorum, Alternaria solani, Verticillium dahliae, Colletotrichum orbiculare, Cytospora juglandis and Curvularia lunata. The preliminary bioassays showed that most of the synthesized compounds exhibited fungicidal activity. Compound in particular exhibited significant antifungal activity against Verticillium dahliae and Sclerotinia sclerotiorum, with the MIC value of 1.95 μg mL-1. Compound also showed excellent activity against six plant pathogen fungi, and was identified as the most active on the biol. assays, and will be studied further.
Natural Product Research published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C20H12N2O2, Name: 2-Chloroisonicotinic acid.
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