Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent was written by Cao, Yangzhi;Kong, Deyu;Sun, Lulu;Meng, Xin;Zhang, Yinyong;Guo, Bin;Yang, Yushe. And the article was included in ChemistrySelect in 2021.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Herein, a modified and improved chem. synthesis of the lead compound, I with the aim to produce from milligrams to 10g of the pure compound that is necessary for the preclin. studies were described. This novel process was one step shorter and started from cheap materials, achieved a sevenfold of the total yield from 0.7% to 5%. Addnl., it avoided the use of palladium on carbon as well as all of the steps involved simple purifications without chromatog. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics