Synthesis of 2,3,4,11b-tetrahydro-1H-pyridazino[6,1-a]isoquinolines via the three-component reaction of 2-alkynylbenzaldehydes, a sulfonylhydrazide and dimethyl cyclopropane-1,1-dicarboxylate was written by Yu, Xingxin;Qiu, Guanyinsheng;Liu, Jianping;Wu, Jie. And the article was included in Synthesis in 2011.COA of Formula: C15H9ClO The following contents are mentioned in the article:
A three-component reaction of 2-alkynylbenzaldehydes, a sulfonylhydrazide and di-Me cyclopropane-1,1-dicarboxylate, co-catalyzed by silver(I) triflate and nickel(II) perchlorate hexahydrate, is described, which affords 2,3,4,11b-tetrahydro-1H-pyridazino[6,1-a]isoquinolines, e.g. I (R = H, F, Cl, O2N), in moderate to good yields. A possible reaction pathway that proceeds via a tandem 6-endo-cyclization and [3 + 3] cycloaddition sequence is proposed. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3COA of Formula: C15H9ClO).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C15H9ClO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics