Solvent-Regulated Coupling of 2-Alkynylbenzaldehydes with Cyclic Amines: Selective Synthesis of Fused N-Heterocycles and Functionalized Naphthalene Derivatives was written by He, Yan;Zheng, Zhi;Liu, Qimeng;Zhang, Xinying;Fan, Xuesen. And the article was included in Organic Letters in 2020.Formula: C15H9ClO The following contents are mentioned in the article:
An efficient synthesis of 1,2,3,4-tetrahydrobenzo[g]quinoline derivatives through PdCl2-catalyzed, TBHP-promoted, and toluene-mediated dehydrogenation/[4+2] cycloaddition of saturated cyclic amines with 2-alkynylbenzaldehydes was developed. On the contrary, when the reaction medium was changed from toluene to DMSO/H2O, another class of important compounds, naphthyl chain amines, formed via a dehydrogenation-intermol. condensation-C-N bond cleavage-intramol. condensation pathway, was obtained with good selectivity. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C15H9ClO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics