Gold-Catalyzed Reaction of ortho-Alkynylarylaldehydes with Conjugated Dienes: An Efficient Access to Highly Strained Tetracyclic Bridgehead Olefins was written by Cao, Ziping;Zhu, Hongbo;Meng, Xin;Tian, Laijin;Sun, Xuejun;Chen, Guang;You, Jinmao. And the article was included in Chemistry – A European Journal in 2016.Formula: C15H9ClO The following contents are mentioned in the article:
An unprecedented access to strained tetracyclic bridgehead alkenes by reaction of easily accessible ortho-alkynylarylaldehydes with conjugated dienes was described. The process involved a chemo- and stereo-selective, gold-catalyzed, tandem intermol. [3+2] cycloaddition/Prins-type ring-closing reaction that allowed generating structural complexity in a straightforward manner. This approach for the preparation of anti-Bredt compounds was synthetically superior to those previously reported: the procedure was easy to implement, operates under mild exptl. conditions, was efficient, and exhibited a good substrate scope. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C15H9ClO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics