Reference of 1939-99-7,Some common heterocyclic compound, 1939-99-7, name is Phenylmethanesulfonyl chloride, molecular formula is C7H7ClO2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 4-Hydroxy benzaldehyde (1.14 g, 9.36 mmol) was dissolved in dichloromethane (20 ml) and to this solutiontriethylamine (1.43 ml, 10.30 mmol) was added drop wisewith stirring. Various substituted sulfonyl chlorides (9.36mmol) were added to the mixture and stirred at room temperature for 24 h. The reaction mixture was extractedwith water (3 ¡Á 20 ml) and brine (3 ¡Á 20 ml) repeatedly for removing triethylamine hydrochloride salt. The organiclayer was dried, solvent removed and the residue wasobtained as solid product.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Phenylmethanesulfonyl chloride, its application will become more common.
Reference:
Article; Mahapatra, Manoj Kumar; Kumar, Rajnish; Kumar, Manoj; Medicinal Chemistry Research; vol. 27; 2; (2018); p. 476 – 487;,
Chloride – Wikipedia,
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