Anchordoguy, Thomas J. published the artcileInsights into the cryoprotective mechanism of dimethyl sulfoxide for phospholipid bilayers, Name: trimethyloxosulphonium chloride, the publication is Cryobiology (1991), 28(5), 467-23, database is CAplus and MEDLINE.
DMSO is a widely used cryoprotectant for biol. structures such as membranes. Despite hundreds of studies on the effects of this mol., surprisingly little is known about its cryoprotective mechanism. This study investigates the ability of various DMSO analogs to serve as cryoprotectants for liposomes. The data show that an increase in hydrophobicity progressively reduces the cryoprotective effect of sulfoxides. Addnl. experiments using phospholipid vesicles of varying composition demonstrate that DMSO is markedly less effective on liposomes carrying a net neg. charge. In fact, cryoprotection by DMSO was virtually eliminated in vesicles composed of 30% phosphatidylserine (a neg. charged lipid). Based on these results, it is suggested that the polar sulfoxide moiety of DMSO interacts electrostatically with phospholipid membranes and that this interaction is critical for DMSO’s cryoprotective effect for membranes.
Cryobiology published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Name: trimethyloxosulphonium chloride.
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https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics