Copper-catalyzed annulation- cyanotrifluoromethylation of 1,6-enynes toward 1-indanones via a radical process was written by Zhang, Tian-Shu;Hao, Wen-Juan;Cai, Pei-Jun;Li, Guigen;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2020.Reference of 1186603-47-3 The following contents are mentioned in the article:
A new Cu(II)-catalyzed annulation-cyanotrifluoromethylation of 1,6-enynes with Togni′s reagent and trimethylsilyl cyanide (TMSCN) has been established, enabling the direct construction of trifluoromethylated 1-indanones with an all-carbon quaternary center in good yields. This reaction was performed by using low-cost Cu(OTf)2 as the catalyst and Togni′s reagent as both the radical initiator and a CF3 source, providing an efficient protocol for building up an 1-indanone framework with wide functional group compatibility. The reaction mechanism was proposed through a radical triggered addition/5-exo-dig cyclization/oxidation/nucleophilic cascade. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Reference of 1186603-47-3).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 1186603-47-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics