An efficient synthesis of 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones catalyzed by HCl involving a Friedel-Crafts alkylation reaction was written by Pan, Wan-Chen;Wang, Yi-Chun;Li, Tuan-Jie;Liu, Jian-Quan;Wang, Xiang-Shan. And the article was included in Journal of Heterocyclic Chemistry in 2020.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:
Aldehydes could underwent not only the subsequent condensation and cyclization with 2-aminothiophene-3-carboxamides to build a pyrimidine ring, but also a Friedel-Crafts alkylation reaction with thiophene moiety to gave unexpected 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones I [R1 = H, Cl, F, Me, MeO; R2 = H, Cl, F, MeO; Ar = Ph, 4-MeC6H4, 4-EtC6H4, 4-n-PrC6H4, 4-ClC6H4] and II [R3 = 2-MeOC6H4, 2-Br-4-FC6H3, 2-furyl, etc.] in good yields catalyzed by concentrated HCl. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics