4-Anilinoquinoline triazines: a novel class of hybrid antimalarial agents was written by Kumar, Ashok;Srivastava, Kumkum;Raja Kumar, S.;Siddiqi, M. I.;Puri, Sunil K.;Sexana, Jitendra K.;Chauhan, Prem M. S.. And the article was included in European Journal of Medicinal Chemistry in 2011.SDS of cas: 2272-40-4 The following contents are mentioned in the article:
A novel class of hybrid 4-anilinoquinoline triazines have been synthesized and evaluated in vitro for their antimalarial activity against CQ-sensitive 3D7 strain of P. falciparum as well as for their cytotoxicity toward VERO cell line. Five compounds exhibited the antimalarial potency superior to CQ. Compounds I and II were found to be orally active at a dose of 100 mg/kg × 4 days against CQ-resistant strain of P. yoelii. Inhibition of β-hematin formation assay and mol. docking study has been conducted in order to gain insight into the mechanism of action of proposed targets for the 4-anilinoquinoline and triazine moiety of the hybrid compounds This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics