Microwave-assisted synthesis of coumarin based 1,3,5-triazinyl piperazines and piperidines and their antimicrobial activities was written by Patel, Divyesh;Patel, Rahul;Kumari, Premlata;Patel, Navin. And the article was included in Acta Poloniae Pharmaceutica in 2012.Reference of 2272-40-4 The following contents are mentioned in the article:
A series of 1,3,5-triazines, containing aniline, 4-hydroxycoumarin, and 7-hydroxy-4-methylcoumarin and different piperazines or piperidines as substituents on the C atoms of the triazine ring, was synthesized by a simple and efficient synthetic protocol. Comparative studies were performed on above compounds, which were synthesized by amination with conventional and microwave heating. The microwave method was observed to be more beneficial as it provides an increase of yield and 90-95% reduction of time. The antimicrobial activity of the compounds was tested against bacteria (S. aureus, B. subtilis, E. coli, P. aeruginosa) and fungi (A. niger, C. albicans). The preliminary in vitro evaluation studies revealed that some of the compounds have promising antimicrobial activities. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Reference of 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Reference of 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics