Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives was written by Zheng, Mingfang;Xu, Chenghui;Ma, Jianwei;Sun, Yan;Du, Feifei;Liu, Hong;Lin, Liping;Li, Chuan;Ding, Jian;Chen, Kaixian;Jiang, Hualiang. And the article was included in Bioorganic & Medicinal Chemistry in 2007.HPLC of Formula: 2272-40-4 The following contents are mentioned in the article:
A series of triaminotriazine derivatives (compounds 5a-f, 6a-x, and 7a-g) was designed, synthesized, and evaluated for their inhibition activities to colorectal cancer (CRC) cell lines (HCT-116 and HT-29). Most of the synthesized compounds demonstrated moderate anti-proliferatory effects on both HCT-116 and HT-29 cell lines at the concentration of 10 μM. The inhibitory activities against HCT-116 and HT-29 cell lines were discussed to develop the structure-activity relationships of this new series. Compounds 6l (I) and 6o exhibited prominent inhibition activities toward HCT-116, with IC50s of 0.76 and 0.92 μM, resp. The in vivo antitumor studies and pharmacokinetics of compound 6l showed that it might be a promising new hit for further development of antitumor agents. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4HPLC of Formula: 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics