Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents was written by Kumar, G. Jagadeesh;Kumar, S. Naveen;Thummuri, Dinesh;Adari, Lavanya Bindu Sree;Naidu, V. G. M.;Srinivas, Kolupula;Rao, V. Jayathirtha. And the article was included in Medicinal Chemistry Research in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
Two new series of s-triazine derivatives appended with benzimidazole and benzothiazole derivatives are synthesized, and structure-activity relationships on anticancer activity of these compounds is probed. In vitro inhibitory activity against the growth of six cancer cell lines, viz., MCF-7, MDAMB-231, PC-3, DU-145, HT-29, and HGC-27 was evaluated for the synthesized analogs. Among the two series of compounds, derivatives containing the benzimidazole scaffold were found to be relatively potent over benzothiazole analogs. In accordance with our previous observation, within benzimidazole derivatives, trisubstituted s-triazine derivatives were found to be more potent over disubstituted derivatives irresp. of cell lines. Structure-activity relationships provided useful insights into these classes of compounds and paved the way to design of novel analogs with more potency. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics