Synthesis and anticancer activity of some new s-triazine derivatives was written by Jagadeesh Kumar, G.;Sriramkumar Bomma, H. V. S.;Srihari, E.;Shrivastava, Shweta;Naidu, V. G. M.;Srinivas, Kolupula;Jayathirtha Rao, V.. And the article was included in Medicinal Chemistry Research in 2013.Related Products of 2272-40-4 The following contents are mentioned in the article:
New s-triazines I (R = C6H5NH, 4-OMeC6H4NH, 4-FC6H4NH, C6H5CH2NH; R1 = Cl, morpholinyl) were synthesized for the structure-activity relationship studies as potent anticancer agents. The prepared analogs were evaluated for their in vitro inhibitory activity against the growth of PA-1 (Ovarian cancer), A549 (Lung cancer), MCF-7 (Breast cancer), and HT-29 (Colon cancer). Tri-substituted s-triazine derivatives with morpholino group on s-triazine scaffold exhibited potent anticancer activities compared to di-substituted s-triazine derivatives These compounds also showed relatively selective PA-1 and HT-29 cancer cell inhibition over other cancer cell lines. Structure-activity relationships provided useful insights in these classes of compounds and paved the way to design novel analogs with more potency. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Related Products of 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics