Related Products of 918538-05-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 918538-05-3 name is 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1A. Preparation of 2-chloro-N-(3-ethyl-1H-pyrazol-5-yl)pyrrolo[1,2-f][1,2,4]triazin-4-amine To a mixture of 3-ethyl-1H-pyrazol-5-amine (100 mg, 0.9 mmol) in isopropylalcohol (1 mL), was added 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (120 mg, 0.64 mmol) and DIEA (0.1 mL, 0.64 mmol). The reaction mixture was stirred at room temperature overnight. The precipitated product was filtered and washed with cold i-PrOH. The solid was dried under N2 overnight to give the title compound. (118 mg, 71%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dichloropyrrolo[2,1-f][1,2,4]triazine, and friends who are interested can also refer to it.
Reference:
Patent; Bristol-Myers Squibb Company; US2008/45496; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics