Design, synthesis, and photochemical properties of clickable caged compounds was written by Suzuki, Akinobu Z.;Shiraishi, Yukiko;Aoki, Hanami;Sasaki, Hirona;Watahiki, Rei;Furuta, Toshiaki. And the article was included in Journal of Visualized Experiments in 2019.Related Products of 638-07-3 The following contents are mentioned in the article:
A method for the synthesis of clickable caged compounds I [R = 3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl, 2-(2-{2-[(6-chlorohexyl)oxy]ethoxy}ethoxy)ethyl] that can be modified easily with various functional units via the copper(I)-catalyzed Huisgen cyclization was reported. The modular platform mol. contains a (6-bromo-7-hydroxycoumarin-4-yl)methyl (Bhc) group as a photo-caging group, which exhibits a high photolysis efficiency compared to those of the conventional 2-nitrobenzyls. General procedures for the preparation of clickable caged compounds containing amines II [R1 = (6-{[(tert-butoxy)carbonyl]amino}hexyl)aminyl], alcs. I [R = prop-2-yn-1-yl], and carboxylates II [R1 = (4Z,7Z,10Z,12Z)-octadeca-4,7,10,12-tetraen-1-yl] are presented. Addnl. properties such as the water solubility and cell targeting ability can be readily incorporated into clickable caged compounds I. Furthermore, the phys. and photochem. properties, including the photolysis quantum yield, were measured and found to be superior to those of the corresponding Bhc caged compounds The described protocol could therefore be considered a potential solution for the lack of structural diversity in the available caged compounds This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Related Products of 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics