Synthesis, antimalarial activity and cytotoxicity of 4-aminoquinoline-triazine conjugates was written by Manohar, Sunny;Khan, Shabana I.;Rawat, Diwan S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.HPLC of Formula: 2272-40-4 The following contents are mentioned in the article:
A series of 4-aminoquinoline-triazine conjugates I [X = (CH2)n, n = 2 – 4, 6, 8; X = CH2CHMe; R1 = Et2N, PhNH, 2-MeC6H4NH, 4-morpholinyl, 1-piperidinyl; R2 = Cl, c-C6H11NH, PhNH, 3,5-(MeO)2C6H3NH, etc.] with different substitution pattern have been synthesized and evaluated for their in vitro antimalarial activity against chloroquine-sensitive and resistant strains of Plasmodium falciparum. Compounds I [X = (CH2)3, (CH2)8; R1 = 4-morpholinyl; R2 = 3,5-(MeO)2C6H3NH], I (X = CH2CH2; R1 = R2 = PhNH) and I [X = CH2CH2; R1 = 2-(7-chloroquinolin-4-ylamino)ethylamino; R2 = Cl] exhibited promising antimalarial activity against both strains of P. falciparum. Cytotoxicity of these compounds was tested against three cell lines. Several compounds did not show any cytotoxicity up to a high concentration (48 μM), others exhibited mild toxicities but selective index for antimalarial activity was high for most of these conjugates. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4HPLC of Formula: 2272-40-4).
4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 2272-40-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics