In-situ formation of a hydrophobic deep eutectic solvent based on alpha terpineol and its application in liquid-liquid microextraction of three β-blockers from plasma samples was written by Jouyban, Abolghasem;Ali Farajzadeh, Mir;Afshar Mogaddam, Mohammad Reza;Khodadadeian, Fariba;Nemati, Mahboob;Khoubnasabjafari, Maryam. And the article was included in Microchemical Journal in 2021.Recommanded Product: Tetramethylammonium chloride The following contents are mentioned in the article:
A new microextraction procedure based on liquid-liquid microextraction using a deep eutectic solvent has been used for the extraction of three β-blockers (atenolol, propranolol, and metoprolol) from plasma samples. The enriched analytes were analyzed by gas chromatog.-mass spectrometry. In this study, both of the microextraction and synthesis processes were accelerated by using microwave radiations. In this procedure, 5 mL diluted plasma sample was transferred into a glass test tube and it was mixed with 0.20 g tetramethylammonium chloride. Then 0.5 mL of DMF (as a co-disperser) was mixed with 610μL alpha terpineol and the mixture was dispersed into the solution to form a homogenous solution The tube was placed under microwave radiations for 1 min. By doing so, tetramethylammonium chloride-alpha terpineol deep eutectic solvent was formed in sample solution as tiny droplets and the analytes were extracted into them. Then the tube was cooled with tap water and centrifuged for 5 min at 5000 rpm. Finally 1μL of the deep eutectic solvent was injected into the determination system. Low limits of detection (0.130-0.205 ng mL-1) and quantification (0.435-0.692 ng mL-1), high extraction recovery (72-86%), and good precision (relative standard deviation ≤ 5.3%) were obtained. The introduced method was effectively applied for determination of the β-blockers concentrations in plasma samples. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Recommanded Product: Tetramethylammonium chloride).
Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: Tetramethylammonium chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics