Design, synthesis and applications of fluoride probe based on aromatization of isoquinolinium salts was written by Zhao, Yun-Hui;Yu, Yajun;Guo, Tao;Zhou, Zhihua;Tang, Zilong;Tian, Li. And the article was included in Dyes and Pigments in 2020.Formula: C15H9ClO The following contents are mentioned in the article:
A novel ratiometric fluorescent probe based on aromatization drive of isoquinolinium salts was designed, synthesized to recognize fluoride. The applications showed that the probe has high selectivity and sensitivity to fluoride. Fluoride induces a cascade reaction of hydroxyl deprotection and 1,6-oxidative elimination, and causes a remarkable fluorescence enhancement. The relative fluorescent intensities (I398/I522) increased linearly with F– concentration at 0-9.0μmol L-1. The limit of detection was very low (3.7 nM) due to the intrinsic aromatization drive of probe induced by F–. The recognition mechanism was demonstrated by mass spectrum (MS) and 1H NMR. The in vitro imaging results showed that the new probe BIQS (2-[4-(tert-butyl-diphenyl-silyloxy)-benzyl]-3-(4-methoxy- phenyl) -isoquinolinium nitrate) was membrane-permeable and could be applied into the determination of fluoride ions in living cells. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).
5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C15H9ClO
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics