Synthetic Route of 112-26-5, A common heterocyclic compound, 112-26-5, name is 1,2-Bis(2-chloroethoxy)ethane, molecular formula is C6H12Cl2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 3.2 g (10.1 mmol) of sodium 2-(diphenylphosphoryl) phenolate [10] and 0.93 g (5.0 mmol) of 1,8-dichloro-3,6-dioxaoctane in 7 mL of anhydrous dioxane was placed into the laboratory system with focused microwave heating in hermetically closed glass vial. The mixture was heated at 150C (50 W) for 0.6 h. After cooling, the reaction mixture was poured into 50 mL of water, acidified with conc. HCl to pH 1, and extracted with CHCl3 (3 ¡Á 30 mL). The extract was washed with dilute HCl (2 ¡Á 30 mL), and water (3 ¡Á 35 mL), and evaporated ina vacuum. To the residue 20 mL of diethyl ether was added, and the precipitate was filtered off. The filtrate was chromatographed.
The synthetic route of 112-26-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Baulin; Ivanova; Polyakova; Pyatova; Krivorot’ko; Tsivadze; Russian Journal of General Chemistry; vol. 85; 4; (2015); p. 899 – 905; Zh. Obshch. Khim.; vol. 85; 4; (2015); p. 899 – 905,7;,
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