Cytotoxic effects of coumarin substituted benzimidazolium salts against human prostate and ovarian cancer cells was written by Karatas, Mert Olgun;Tekin, Suat;Alici, Bulent;Sandal, Suleyman. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
The synthesis and anticancer properties of 6-substituted 4-chloromethylene coumarin derivatives I (R1 = Me, Et, ethoxy, iso-Pr, tert-Bu, benzyl) and benzimidazole derivatives II (R2 = Ph, 2,3,4,5,6-pentamethylphenyl, 3,4,5-trimethoxyphenyl), III (R3 = Ph, 2,3,4,5,6-pentamethylphenyl) and IV were reported. For this purpose, six 6-substituted-4-chloromethylene coumarin derivatives I and benzimidazole derivatives II, III and IV were synthesized and characterized. All compounds I, II, III, IV performed significant cytotoxicities at 100μM against human prostate (PC-3) and ovarian (A2780) cancer cell lines. Moreover, some compounds performed significant activities at 1μM against PC-3 and A2780 cancer cell lines and the obtained results suggest that this type of compounds is promising candidate for the treatment of human prostate and ovarian cancers. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics