Rapid analysis of benzalkonium chloride using paper spray mass spectrometry was written by Liu, Jingjing;Deng, Wenjie;Yu, Muqian;Wen, Ruizhi;Yao, Shouzhuo;Chen, Bo. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2017.Electric Literature of C25H46ClN The following contents are mentioned in the article:
A paper spray mass spectrometry (PS-MS) method for rapid and reliable anal. of benzalkonium chloride (BAC) in compound eye drops and body surface disinfectant was developed. The sample was dropped onto triangular filter paper, and high voltage (3.5 kV) was applied to form an electrospray. This method can provide the composition of benzalkonium chloride in samples without pretreatment, solvent or chromatog. separation, and the anal. time is only 10 s. The primary homologs C12-BAC, C14-BAC and C16-BAC of benzalkonium chloride were quant. analyzed using PS-MS. Samples were subjected to simple dilution and quantified using the internal standard method. Ion trap mass spectrometry was scanned using SIM mode. The linear ranges of C12-BAC, C14-BAC and C16-BAC were 1-100 μg mL-1; the linear regression coefficients were 0.998-0.999; the detection limits (LODs) were 0.1 μg mL-1; the limit of quantifications (LOQs) was <1 μg mL-1, and the method validation indicated that the method precision and accuracy were good. Compared with HPLC-UV methods, there was no significant difference in the quant. determination of the actual samples, but the anal. time for PS-MS is shorter (2 min). In addition, reagent consumption in PS-MS is small, and no chromatog. separation is needed, suggesting that PS-MS is especially suitable for high-throughput anal. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Electric Literature of C25H46ClN).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Electric Literature of C25H46ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics