Fast detection of benzalkonium chloride in eye drops based on nano electrospray-portable ion trap mass spectrometry was written by Zha, Yue;Shen, Xuejing;Li, Ming. And the article was included in Fenxi Shiyanshi in 2021.Computed Properties of C25H46ClN The following contents are mentioned in the article:
In this work, a rapid detection method without using chromatog. for the determination of bactericidal component of benzalkonium chloride in com. eye drops was established by building a nanoelectrospray ionization (Nano-ESI) with portable ion trap mass spectrometer (Ion Trap MS). In the pos. ion mode, the eye drops sample was diluted and injected into the capillary for rapid qual. and quant. anal. The optimal anal. conditions were obtained as follows, the distance between the capillary outlet and the injection port was 10 mm, and the spray voltage was 2000 V, the capillary voltage, capillary temperature and ion funnel voltage were set at 5 V, 30°C and 40 V, resp. The [M-Cl]+ peaks of three benzalkonium chlorides were used as qual. criteria, and the solution was prepared with pure substance and then analyzed by quant. anal. of standard curves. Under the optimized conditions, the linear range of the three components in the diluted eye drops was 1-500 mg/L with good correlation coefficient (R2> 0.99). The limit of detection (LOD) of the method evaluated by 11 blank sample test results was 0.1 mg/L and the limit of quantification (LQD) was 0.33 mg/L. Compared with the ultrahigh performance liquid chromatog. (UPLC)-MS method, there was no significant difference between the quant. determination results for the actual samples, but the anal. time of the Nano-ESI MS method was shorter (2 min). Therefore, the method can be used for rapid screening and quant. determination of benzalkonium chloride as an additive in eye drops. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Computed Properties of C25H46ClN).
N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C25H46ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics