Reference of 6940-78-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6940-78-9 name is 1-Bromo-4-chlorobutane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
3.53 g of 1-bromo-4-chlorobutane (20.6 mmol) was dissolved in 50 ml of absolute ethanol, added to a 500 ml round bottom flask,Set 0 C in an ice bath with stirring, with a constant pressure dropping funnel was slowly added dropwise 3.11g50% sodium methanethiolate (22.2mmol) absolute ethanolLiquid, naturally warmed to room temperature, overnight, the total reaction time is not less than 24h. Stop stirring, remove the ethanol by vacuum low temperature cyclization to positiveHexane three consecutive extraction, the extract was dried over anhydrous sodium sulfate, insoluble matter was filtered off. Remove the n-hexane by vacuum evaporation at low temperature to obtain the product2.69 g of a colorless oil with a strong mustard odor and an intermediate content of about 81% as determined by GC-MS. The intermediate yield was about76.3%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-chlorobutane, and friends who are interested can also refer to it.
Reference:
Patent; Taishan Medical School; Li Binglong; Liu Changli; Zhao Shizhen; Qi Yongxiu; Xia Chengcai; Li Furong; Li Ke; Hao Liyong; Guan Xidong; (6 pag.)CN106866478; (2017); A;,
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