Development and validation of vortex-assisted dispersive liquid-liquid microextraction method based on solidification of floating hydrophobic deep eutectic solvent for the determination of endocrine disrupting chemicals in sewage was written by Wu, Youyi;Chen, Mengxuan;Wang, Xuedong;Zhou, Yunlu;Xu, Mengqi;Zhang, Zhanen. And the article was included in Microchemical Journal in 2021.Synthetic Route of C25H54ClN The following contents are mentioned in the article:
Herein, we newly synthesized twenty kinds of hydrophobic deep eutectic solvents (HDESs) using long-chain fatty alcs., fatty acids, quaternary ammonium salts and menthol as hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs). Based on their physicochem. properties, six of HDESs with low d. and m.p. were selected for further investigation. After screening, one kind of HDES composed of 1-dodecanol (HBD) and octanoic acid (HBA) was chosen as the extraction solvent. Using vortexing instead of traditional dispersive solvent, a newly dispersive liquid-liquid microextraction method based on solidification of floating hydrophobic DES (DLLME-SFHDES) was developed to enrich endocrine disrupting chems. in sewage and analyzed by HPLC with fluorescence detector. Single-factor optimization was performed, and three key factors were selected with a Plackett-Burman design. The optimal factors were further evaluated and verified by a central composite design. Under the optimal extraction conditions, the proposed method showed a good linear relationship in the ranges of 4.39-5000 ng L-1 (r2 > 0.9994) for estradiol, estriol, bisphenol A and bisphenol F. The limits of detection (S/N = 3) and quantification (S/N = 10) were 1.33-2.92 and 4.39-9.64 ng L-1, resp. The intra-day and inter-day precision (n = 6) were less than 6.2%, and the obtained enrichment factors were in the range of 96-111. Four endocrine disrupting chems. within 59-11,000 ng L-1 were detected in sewage samples from three local wastewater treatment plants with good recoveries (85.3-112%). In general, the vortex assisted DLLME-SFHDES method was proved to be a green alternative for the determination of endocrine disrupting chems. in environmental waters. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Synthetic Route of C25H54ClN).
N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C25H54ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics