Zhang, Deyi published the artcileDiscovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores, Product Details of C6H4ClNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(19), 4337-4341, database is CAplus and MEDLINE.
Preclin. experiments and clin. observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the indole nucleus in LY334370 (I) with a monocyclic Ph ketone moiety generated potent and more selective 5-HT1F receptor agonists. Focused SAR studies around this central Ph ring demonstrated that the electrostatic and steric interactions of the substituent with both the amide CONH group and the ketone C=O group play pivotal roles in affecting the adopted conformation and thus the 5-HT1F receptor selectivity. Computational studies confirmed the observed results and provide a useful tool in the understanding of the conformational requirements for 5-HT1F receptor agonist activity and selectivity. Through this effort, the 2-F-Ph and N-2-pyridyl series were also identified as potent and selective 5-HT1F receptor agonists.
Bioorganic & Medicinal Chemistry Letters published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C14H12O2, Product Details of C6H4ClNO2.
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Chlorides – an overview | ScienceDirect Topics