McDermott, Todd S.’s team published research in Organic Process Research & Development in 13 | CAS: 6313-54-8

McDermott, Todd S. published the artcileDevelopment of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279, Computed Properties of 6313-54-8, the publication is Organic Process Research & Development (2009), 13(6), 1145-1155, database is CAplus.

A convergent, scalable synthesis of dipeptidyl peptidase-4 inhibitor, ABT-279 (I), was developed and demonstrated on multikilogram scale. The cis-2,5-disubstituted pyrrolidine was generated by cyclization of a Boc-amine onto an alkynyl ketone followed by stereospecific reduction of the resulting acyliminium intermediate. The amine coupling partner was prepared by a novel Hofmann rearrangement promoted by 1,3-dibromo-5,5-dimethylhydantoin. The final product was isolated as the L-malic acid salt. The scale-up campaign consisted of 15 steps and delivered 42 kg of ABT-279 in 14% overall yield. A second-generation synthesis that addresses some of the issues encountered during scale-up was developed and demonstrated on kilogram scale.

Organic Process Research & Development published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics